Glyoxlate is usually converted into the amino acid glycine. This processs occurs tas a result of the action of the enzymes alanine-glyoxylate aminotransferase and glyoxlate reductase. Mutations in two genes can result in the reduction of these enzymes.
Because of this reduction, there will be less production of glycine. Glyoxylate levels will as a result build up. The build up eventually results in the conversion of glyoxylate into oxalate (Michael, 2011). Oxalate then combines with calcium. It then precipitates into a solid substance. This solid substance cannot be easily excreted from the body and as a result of this it might result in the infliction of damage to the kidneys and other organs.